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Experts think the steroids help decrease inflammation and may influence the repair of weakened muscle cell membranesthrough increased production of a protein called collagen. Both of these benefits have been shown in animal studies, and research is currently underway to prove the same effect in humans. In the case of Rofek, the positive benefits could not be observed in the two years prior to his injury which may be partially attributed to a different type of steroid he used. "Our previous work with our animal model and in the literature has shown that the synthetic human steroid Rofekol can improve muscle strength in animals, and even promote recovery of muscular functions," said senior investigator Dr. Michael DeRienzo, professor and former director of Penn's Center on Aging and Brain Sciences. "In the case of Rofekol, the steroid may contribute to long-term muscle health and strength." Other Penn researchers involved in the research include postdoctoral researcher and first author Dr. Jeffrey A. Lee, associate professor of mechanical and biomedical engineering and of biophysics and director of the Penn Accelerated Human Cardiovascular and Longevity (AAHL) Science Center; Dr. Rishi Kumar, a faculty fellow; and Dr. James C. Williams, a distinguished professor of applied human physiology and of molecular and cellular physiology. The research was conducted in collaboration with Penn's Institute for Research Into Aging, the University's Center for Aging Research, and the Institute for Quantitative Biology and Biomarkers. Funding for the research came from the David & Lucile Packard Fund, the National Endowment for the Humanities and the National Institute on Aging. Similar articles: